研究方向

离子-通道工程（Molecular & Cellular Bioengineering and Physiology）

1. 钙通道蛋白（生物物理/工程🦸🏼‍♂️；调控多肽）

2. 钙离子信号（分子生理/病理💇；荧光探针）

教育与工作经历

学术兼职

中国生物医学工程学会 生物医学测量分会  副主任委员

中国神经科学会 离子通道与受体分会  常务会员

中国生物物理学会 钙信号分会  委员 

主要学术荣誉

北京凯发K8娱乐平台注册官方网站医工百人教授

清华大学优秀博士论文指导教师

科研项目

国自然面上 81971728 (PI) from NSFC, China 2024-2027

国自然面上 81971728 (PI) from NSFC, China 2020-2023

北自然重点 7191006 (PI) from BNSF, Beijing, China 2019-2021

国自然面上 21778034 (PI) from NSFC, China 2018-2021

国自然面上 31370822 (PI) from NSFC, China 2014-2017

北自然面上 7142089 (PI) from BNSF, Beijing, China 2014-2016

国自然面上 81171382 (PI) from NSFC, China 2012-2015

科技部973计划 2011CB707701 (Co-PI), China 2011-2015 

代表性研究论文

1.       Geng JL#, Yang YX#, Li BY#, Yu Z#, Qiu S#, et al., Fan YB*, Xing CF*, Liu XD* (刘晓冬) (2024) Opto-chemogenetic inhibition of L-type Ca_V1 channels in neurons through a membrane-assisted molecular linkage. Cell Reports Methods DOI: 10.1016/j.crmeth.2024.100898.

https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(24)00288-1

2.       Yang YX#, Geng JL#, YU Z#, et al., Li XM*, Fan YB* and Liu XD* (刘晓冬) (2022) Cytosolic peptides encoding Ca_V1 C-termini downregulate the calcium channel activity-neuritogenesis coupling. Communications Biology DOI: 10.1038/s42003-022-03438-1.

https://www.nature.com/articles/s42003-022-03438-1

3.       Geng JL#, TangYJ#, Yu Z#, Gao YM, Li WZ, Lu YT, Wang B, Zhou HM, Li P, Liu N, Wang P, Fan YB, Yang YX*, Guo ZC*, Liu XD* (刘晓冬) (2022) Chronic Ca²⁺ imaging of cortical neurons with long-term expression of GCaMP-X. eLife DOI: 10.7554/eLife.76691.

https://elifesciences.org/articles/76691

4.       Yang YX#, Liu N#, He Y#, Liu YX, Ge L, Zou LZ, Song S, Xiong W and Liu XD* (刘晓冬) (2018) Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP. Nature Communications DOI: 10.1038/s41467-018-03719-6. (Faculty of 1000)

https://www.nature.com/articles/s41467-018-03719-6  

5.       Su Q#, Hu FZ#, Liu YX#, Ge XF, Mei CL, Yu SQ, Shen AW, Zhou Q, Yan CY, Lei JL, Zhang YQ∗, Liu XD* (刘晓冬) and Wang TL∗ (2018) Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. Nature Communications DOI: 10.1038/s41467-018-03606-0.

https://www.nature.com/articles/s41467-018-03606-0

6.       Liu N#, Yang YX#, Ge L#, Liu M, Colecraft HM and Liu XD* (刘晓冬) (2017) Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca²⁺ channels, eLife DOI: 10.7554/eLife.21989.

http://elifesciences.org/content/6/e21989

7.       Hu M#, Liu Y#, Wu J# and Liu XD* (刘晓冬) (2015) Influx-operated Ca²⁺ entry via PKD2-L1/PKD1-L3 channels facilitates sensory responses to polymodal transient stimuli. Cell Reports DOI: 10.1016/j.celrep.2015.09.041.

https://www.cell.com/cell-reports/abstract/S2211-1247(15)01066-9

8.       Liu XD* (刘晓冬), Yang PS, Yang W, and Yue DT* (2010) Enzyme-inhibitor-like tuning of Ca²⁺ channel connectivity with calmodulin. Nature DOI:10.1038/nature08766. (Faculty of 1000)

           https://www.nature.com/articles/nature08766